Safe Returner v 1.27 has dramatically improved in comparison to previous builds.
I have tested it more and more times.
It is good against Zeus Trojan, SpyEye Trojan/Keylogger (which can be installed even on Limited User Account - LUA) and some rootkits and rogue.
It is quite effective in an already infected machine, just pay attention to some possible false positive detections.
It missed a TDSS rootkit (a probably unknown variant) and a rogue during my tests but it cacthed all Zeus and SpyEye variants.
Not that bad, I think the price is not cheap and however cannot replace applications like MalwareBytes' Antimalware and SUPERAntispyware (In my opinion) but I'm sure that
egomoo, the developer is working hard to improve his SafeRetuner
http://forum.raymond.cc/security-bulletin/21984-safe-returner-1-27-released.html